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張中興教授/主任

張中興 教授

張中興　教授

最高學歷： 高雄醫學大學醫學博士
現任經歷： 慈濟大學醫學科學研究所教授、花蓮慈濟醫院皮膚醫學中心主任/主治醫師、中央研究院應用科學中心合聘研究員
研究領域：皮膚生理學、皮膚免疫學、發育生物學、再生醫學、轉譯醫學
電話：03-8561825分機  12180
電子信箱：chchang@mail.tcu.edu.tw；miriamchangch@gmail.com

近年指導研究生名單：

鄒牧帆，慈濟大學轉譯醫學博士學位學程

【2016-2021年Major Publications】

  1. Joon-Khim Loh, Ching-Chih Lin, Ming-Chang Yang, Chia-Hua Chou, Wan-Shia Chen, Ming-Chang Hong, Chung-Lung Cho, Ching-Mei Hsu, Jiin-Tsuey Cheng, An-Kuo Chou, Chung-Hsing Chang, Chao-Neng Tseng, Chi-Huei Wang, Ann-Shung Lieu, Shen-Long Howng, Yi-Ren Hong. GSKIP- and GSK3-mediated anchoring strengthens cAMP/PKA/Drp1 axis signaling in the regulation of mitochondrial elongation. BBA-Molecular Cell Research. 2015 Aug; 1850 (8):1796-807. DOI:10.1016/j.bbamcr.2015.04.013
  2. Chin-Pin Chen, Chung-Hsing Chang*, Tso-Tsai Liu, Ruey-Ho Kao, Yung-Hsiang Hsu. Primary systemic amyloidosis with multiple myeloma presenting with unusual pancreatitis and colitis. Dermatol Sin 2015 Sep; 33(3): 173-4. DOI:1016/j.dsi.2014.10.002
  3. Chao-Yang Lai, Da-Wei Yeh, Chih-Hao Lu, Yi-Ling Liu, Li-Rung Huang, Cheng-Yuan Kao, Huan-Yuan Chen, Chi-Ying F. Huang, Chung-Hsing Chang, Yunping Luo, Rong Xiang and Tsung-Hsien Chuang. Identification of Thiostrepton as a Novel Inhibitor for Psoriasis-like Inflammation Induced by TLR7-9. J Immunol.2015 Oct 15; 195(8):3912-21. DOI:10.1049/jimmunol.1500194
  4. Chien-Hsing Lee, Ping-Shan Lai, Yen-Pei Lu, Hsuan-Ying Chen, Chee-Yin Chai, Rong-Kung Tsai, Kang-Tang Fang, Ming-Hsien Tsai, Chia-Yen Hsu, Chun-Cheng Hung, Deng-Chyang Wu, Hsin-Su Yu, Chung-Hsing Chang*, Din-Ping Tsai. Real-time vascular image and photodynamic therapy efficacy with micelle-nanocarrier facilitating the delivery of chlorin e6 to the microenvironment of melanoma. J Dermatol Sci. 2015 Nov; 80(2): 124-32. DOI:10.1016/j.jdermsci.2015.05.005
  5. Shun-Ping Huang, Kan-Tang Fang, Chung-Hsing Chang, Tzu-Lun Huang, Yao-Tseng Weng, Rong-Kung Tsai. Autocrine protective mechanisms of human granulocyte colony-stimulating factor (G-CSF) on retinal ganglion cells after optic nerve crush. Exp Eye Res.2016 Feb; 143:132-40. DOI:10.1016/j.exer.2015.10.010
  6. Yu-Hung Kuo, Chung-Hsing Chang*. Erythrodermic mycosis fungoides treated with low-dose methotrexate and 311nm UVB: A case report with 3-year follow up and literature review. Dermatol Sin 2016 Mar; 34(1):37-41.DOI:10.1016/j.dsi.2015.07.009 DOI:1016/j.dsi.2015.07.009
  7. Lin Hsiao-Yu, Hsu Chung-Hao, Cheng Shih-Tsung, Chung-Hsing Chang*. Imatinib-induced exacerbation of psoriasis in a patient with recurrent dermatofibrosarcoma protuberans: A case report and review of the literature. Dermatol Sin 2016 Mar; 34(1)26-8. DOI:10.1016/j.dsi.2015.02.006
  8. Tzu-Lun Huang , Yao-Tseng Wen , Chung-Hsing Chang, Chu-Wen Chang , Kung-Hung Lin, Rong-Kung Tsai. Efficacy of intravitreal injections of triamcinolone acetonide in a rodent model of non-arteritic anterior ischemic optic neuropathy. Invest Ophthalmol Vis Sci2016 Apr; 57(4):1878-84. DOI:10.1167/iovs.15-19023
  9. Ching-Yin Wu, Chung-Hsing Chang*. Treating recalcitrant verruca vulgaris in a pediatric patient with H2 blocker: An easy alternative approach. J Formos Med Assoc2016 May; 115 (5):380-1. DOI:10.1016/j.jfma.2015.06.011
  10. Ming-Hsien Tsai, Chung-Hsing Chang*, Rong-Kung Tsai, Yi-Ren Hong, Tsung-Hsien Chuang, Kan-Tang Fan, Chi-Wen Peng, Wen-Li Hsu, Lih-Shinn Wang, Li-Kuang Chen, Ching-Ying Wu, Hsin-Su Yu. Cross regulation of Interleukin-10 and miR-155 in the production of pro-inflammatory cytokines in Orientia tsutsugamushi-infected human macrophages prevents cytokine storm. J Invest Dermatol.2016 Jul; 136 (7):1398-407. DOI:10.1016/j.jid.2015.11.034
  11. Ching-Ying Wu , Wen-Li Hsu ,Chun-Hsiung Wang ,Jui-Lin Liang,,Ming-Hsien Tsai, Chia-Jung Yen, Hsiu-Wen Li, Siou-Jin Chiu, Chung-Hsing Chang,Yaw-Bin Huang, Ming-Wei Lin,Tohru Yoshioka. A Novel Strategy for TNF-Alpha Production by 2-APB Induced Downregulated SOCE and Upregulated HSP70 in O. tsutsugamushi-Infected Human Macrophages. PLoS One. 2016 Jul; 11(7): e0159299. DOI:10.1371/journal.pone.0159299
  12. Chung-Hsing Chang, Yu-HsuanLin, Cheng-Ru Li, Chun-Ming Chang, Chih-WeiHung, Han-Chao Chang. Developing a dermatological photodiagnosis system by optical image analyses and in vivo study. Photodiagnosis Photodyn Ther. 2016 Sep; 15,100-4. DOI:10.1016/j.pdpdt.2016.06.004
  13. Yao-Tseng Wen, Tzu-Lun Huang, Sung-Ping Huang, Chung-Hsing Chang*, Rong-Kung Tsai*. Early applications of granulocyte colony-stimulating factor (G-CSF) can stabilize the blood-optic nerve barrier and further ameliorate optic nerve inflammation in a rat model of anterior ischemic optic neuropathy (rAION). Dis Model Mech2016 Oct 1;9 (10):1193-1202. DOI: 1242/dmm.025999
  14. Tzu-Lun Huang, Yao-Tseng Wen, Chung-Hsing Chang, Shu-Wen Chang, Kuan-Hung Lin, Rong-Kung Tsai. Early Methylprednisolone treatment can stabilize the blood-optic nerve barrier in a rat model of anterior ischemic optic neuropathy (rAION). Invest Ophthalmol Vis Sci. 2017 Mar 1; 58 (3):1628-1636.DOI:10.1167/iovs.16-21017
  15. Ping-Song Chou, Tsai-Ching Chou, Chung-Hsing Chang, Sebastian Yu, Chih-Hung Lee. Chronic eczematous dermatitis in patients with neurodegenerative diseases may be an early marker of bullous pemphigoid. Med Hypotheses. 2017 Jun;103:86-89. DOI:10.1016/j.mehy.2017.04.017
  16. Shiang-YuYang, Chih-HungLin, Chung-Hsing Chang*. Bullous Sweet’s syndrome with figurate erythema and cutaneous hemophagocytosis. Dermatol Sin 2017 Sep; 35(3):148-51.DOI:10.1016/j.dsi.2017.02.008
  1. Chung-Hsing Chang*, Che-Jung Kuo, Takamichi Ito, Yu-Ya Su, Si-Tse Jiang, Min-Hsi Chiou, Yu-Hsiang Lin, Andrea Nist, Marco Mernberger, Thorsten Stiewe, Shosuke Ito, Kazumasa Wakamatsu, Yi-An Hsueh, Sheau-Yann Shieh, Irit Alkalay, Yinon Ben-Neriah. CK1α ablation in keratinocytes induces p53-dependent, sunburn-protective, skin hyperpigmentation. Natl. Acad. Sci. U.S.A (PNAS). 2017 Sep; 114(38), E8035-E8044. DOI:10.1073/pnas.1702763114
  2. Wan-Chieh Shen, Chung-Hsing Chang*. Wells syndrome (eosinophilic cellulitis) caused by adrenal insufficiency and relieved by cortisone supplementation. J Formos Med Assoc. 2018 May; 117(5):450-451.DOI:10.1016/j.jfma.2018.01.01
  3. Chao-Chun Yang, Tak-Wah Wong, Chih-Hung Lee, Chien-Hui Hong, Chung-Hsing Chang, Feng-Jie Lai, Shang-Hung Lin, Ching-Chi Chi, Tzu-Kai Lin, Hsi Yen, Chin-Han Wu, Hamm-Ming Sheu ,Cheng-Che E. Lan. Efficacy and safety of topical SR-T100 gel in treating actinic keratosis in Taiwan: A Phase III randomized double-blind vehicle-controlled parallel trial. J Dermatol Sci. 2018 Jun; 90(3):295-302. DOI:10.1016/j.jdermsci.2018.02.015
  4. Shiang-Yu Yang, Chung-Hsing Chang*. Bacilli-containing granuloma with subsequent granuloma annulare-like eruptions following Bacillus Calmette–Guérin vaccination. Pediatr Neonatol. 2018 Oct; 59(5):525-526. DOI:10.1016/j.pedneo.2017.12.004
  5. Chih-Hao Lu, Chao-Yang Lai, Da-Wei Yeh, Yi-Ling Liu, Yu-Wen Su, Li-Chung Hsu, Chung-Hsing Chang, S.-L. Catherine Jin, Tsung-Hsien Chuang. Involvement of M1 Macrophage Polarization in Endosomal Toll-Like Receptors Activated Psoriatic Inflammation. Mediators of Inflammation. Volume 2018, Article ID 3523642, 14 pages. DOI:10.1155/2018/3523642
  6. Kai-Chi Tsai, Jen-Hung Wang, Sung-Jen Hung, Shyh-Jer Huang, Chien-Hsing Wang, Jiunn-Tat Lee, Chia-Yi Lee, Chung-Hsing Chang*. Cutaneous malignant melanoma in Eastern Taiwan: clinicopathologic analysis of 56 cases. Dermatol Sin 2019 Oct-Dec; 37(4):187-193. DOI: 10.4103/ds.ds_13_19
  7. Pei-Yu Lai, Chung-Hsing Chang, Hong-Ren Su, Wen-Chuan Kuo. Lymphatic vessel segmentation in optical coherence tomography by adding U-Net-based CNN for artifact minimization. Biomedical Optics Express 2020 Apr 23;11(5):2679-2693. DOI: 10.1364/BOE.389373.
  8. Lin JD, Liu DW, Li MH, Chang CH*. Radiotherapy for invasive extramammary Paget’s disease: A case report. Dermatol Sin 2020;38:250-1
  9. Wei-Wen Sung, Chung-Hsing Chang*. Nevi, dysplastic nevi and melanoma: molecular mechanisms in the progression. Tzu Chi Med J Date of Web Publication16-Jul-2021. DOI:10.4103/tcmj.tcmj_158_20.
  10. Pei-Yu Lai, Tai-Yu Shin, Yu-Huan Chang, Ya-Shuan Chou, Ting-Hua Wu, Yu-Ya Su, Chung-Hsing Chang* Wen-Chuan Kuo. In vivo longitudinal tracking of lymphangiogenesis and angiogenesis in cutaneous melanoma mouse model using multifunctional optical coherence tomography. JID Innovations (2021);1:100010. DOI:/10.1016/j.xjidi.2021.100010
  11. Yu‑Pei Lo, Desale Snehal, Lu‑Hau Deng, Chung‑Hsing Chang*, Chao‑Jen Shih. Successful treatment of acquired reactive perforating collagenosis induced by pregnancy with allopurinol: A Case report with review of literature. Dermatol Sin 2021 July-Sep;37(3):162-165. DOI: 10.4103/ds.ds_47_18
  12. Chen WY, Chang CY, Chang TW, Chung-Hsing Chang*. Characteristics of the blisters of varicella-zoster viral infection on cutaneous optical coherence tomography. Dermatol Sin 2021;39:81-2. DOI: 10.4103/ds.ds_56_20
  13. Chen YT, Chung-Hsing Chang*. Tocilizumab-induced psoriasis in a patient with rheumatoid arthritis: A case report and literature review. Dermatol Sin 2021;39:89-90. DOI: 10.4103/ds.ds_57_20
  14. Ro-Wei Wu, Ming-Hsun Li, Chung-Hsing Chang*. Pseudolymphomatous folliculitis presenting as an eruptive nodule over the mandibular area. J Cutan Pathol. 2021 Mar 1.DOI: 10.1111/cup.13951.
  15. Wang WE, Wu RW, Chung-Hsing Chang*. An elderly female with pemphigus foliaceus possibly induced by losartan/hydrochlorothiazide. Dermatol Sin 2021;39:107-8. DOI:4103/ds.ds_9_21
  16. Lin JD, Li MH, Wu TH, Chang CH*. Combined methyl aminolevulinate-based photodynamic therapy and imiquimod in a patient with perianal extramammary Paget’s disease. Photodiagnosis Photodyn Ther. 2021 Sep;35:102407. doi: 10.1016/j.pdpdt.2021.102407. Epub 2021 Jun 17. PMID: 34146719.
  17. Weng HY, Wu RW, Chen YT, Lin YF, Liu YM, Tsai SF, Chang CH*. Novel ADAR1 mutations in three cases of psoriasis coexisting with dyschromatosis symmetrica hereditaria. J Eur Acad Dermatol Venereol. 2022 Jan;36(1):e54-e57. doi: 10.1111/jdv.17620. Epub 2021 Sep 1. PMID: 34418169.
  18. Alex Chen WY, Chang CH*. The minimal erythema dose of narrowband ultraviolet B in elderly Taiwanese. Photodermatol Photoimmunol Photomed. 2021 Sep 1. doi: 10.1111/phpp.12730. Epub ahead of print. PMID: 34467564.
  19. Chen YT, Liu WS, Su KY, Hsu YH, Chang CH*. Acute heart failure with dilated cardiomyopathy as the first manifestation of eosinophilic granulomatosis with polyangiitis. J Eur Acad Dermatol Venereol. 2021 Sep 23. doi: 10.1111/jdv.17693. Epub ahead of print. PMID: 34553425.
  20. Chen TL, Yip HT, Wang JH, Chang CH, Huang C, Hsu CY, Chang CH*. Risk of chronic spontaneous urticaria in reproductive-aged women with abnormal uterine bleeding: A population-based cohort study. J Dermatol. 2021 Nov;48(11):1754-1762. doi: 10.1111/1346-8138.16109. Epub 2021 Aug 30. PMID: 34462945.
  21. Chia-Hsiung Lin, Chung-Hsing Chang*. Bacteria induced pigmented clear cell acanthosis of the nipple and areola. Dermatol Sin 2021(accepted).
  22. Sung WW, Chang CH*. Nevi, dysplastic nevi, and melanoma: Molecular and immune mechanisms involving the progression. Tzu Chi Med J. 2021 Jul 16; 34(1):1-7.
  23. Lai PY, Shih TY, Chang YH, Chou YS, Wu TH, Su YY, Chang CH*, Kuo WC. In Vivo Longitudinal Tracking of Lymphangiogenesis and Angiogenesis in Cutaneous Melanoma Mouse Model Using Multifunctional Optical Coherence Tomography. JID Innov. 2021 Mar 18; 1(2):100010.

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